Phosphatidylinositol 3-kinase signaling in mammalian preimplantation embryo development.

  title={Phosphatidylinositol 3-kinase signaling in mammalian preimplantation embryo development.},
  author={Christopher O'Neill},
  volume={136 2},
The development of the preimplantation mammalian embryo is an autopoietic process; once initiated development proceeds without an absolute requirement for external information or growth cues. This developmental autonomy is partly explained by the generation of autocrine trophic ligands that are released and act back on the embryo via specific receptors. Several embryotrophic ligands cause receptor-dependent activation of 1-o-phosphatidylinositol 3-kinase. This enzyme phosphorylates… CONTINUE READING