Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1.

@article{Jiang2001Phosphatidylinositol3S,
  title={Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1.},
  author={Bin Jiang and Guoqiang Jiang and Jenny Z. Zheng and Zhimin Lu and Tony Hunter and Peter K. Vogt},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={2001},
  volume={12 7},
  pages={363-9}
}
The phosphatidylinositol 3-kinase (PI3K) signaling pathway has inherent oncogenic potential. It is up-regulated in diverse human cancers by either a gain of function in PI3K itself or in its downstream target Akt or by a loss of function in the negative regulator PTEN. However, the complete consequences of this up-regulation are not known. Here we show that insulin and epidermal growth factor or an inactivating mutation in the tumor suppressor PTEN specifically increase the protein levels of… CONTINUE READING
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