Phosphatidylinositol 3 kinase pathway and 4-hydroxy-2-nonenal-induced oxidative injury in the RPE.

@article{Chen2009Phosphatidylinositol3K,
  title={Phosphatidylinositol 3 kinase pathway and 4-hydroxy-2-nonenal-induced oxidative injury in the RPE.},
  author={Jianbin Chen and Ling Wang and Yan Chen and Paul Sternberg and Jiyang Cai},
  journal={Investigative ophthalmology & visual science},
  year={2009},
  volume={50 2},
  pages={936-42}
}
PURPOSE 4-Hydroxy-2-nonenal (4-HNE) is a major lipid peroxidation product in the retina and the retinal pigment epithelium. The purpose of the present study was to investigate how NF-E2-related factor-2 (Nrf2) and phosphatidylinositol 3 (PI3K) pathways affect the responses of cultured human retinal pigment epithelial (RPE) cells to 4-HNE. METHODS Cultured ARPE-19 cells were treated with different concentrations of 4-HNE and a PI3K inhibitor, LY294002. Intracellular glutathione (GSH) was… CONTINUE READING
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Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido an alkynyl derivatives

  • A Vial, KA Tallman, AT Jacobs, DC Liebler, NA Porter, LJ. Marnett
  • Chem Res
  • 2009
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