Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation.

@article{Krymskaya1999Phosphatidylinositol3M,
  title={Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation.},
  author={Vera P Krymskaya and Raymond B. Penn and M J Orsini and P H Scott and Robin J Plevin and T R Walker and Andrew J Eszterhas and Y Amrani and Edwin R Chilvers and Reynold A Panettieri},
  journal={The American journal of physiology},
  year={1999},
  volume={277 1 Pt 1},
  pages={L65-78}
}
Hypertrophy and hyperplasia of airway smooth muscle (ASM) are important pathological features that contribute to airflow obstruction in chronic severe asthma. Despite considerable research effort, the cellular mechanisms that modulate ASM growth remain unknown. Recent evidence suggests that mitogen-induced activation of phosphoinositide (PI)-specific phospholipase C (PLC) and PI-dependent calcium mobilization are neither sufficient nor necessary to stimulate human ASM proliferation. In this… CONTINUE READING