Phosphatidylinositol 3-kinase is required for growth factor-induced amino acid uptake by vascular smooth muscle cells.

@article{Higaki1999Phosphatidylinositol3I,
  title={Phosphatidylinositol 3-kinase is required for growth factor-induced amino acid uptake by vascular smooth muscle cells.},
  author={Mika Higaki and Kentaro Shimokado},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1999},
  volume={19 9},
  pages={2127-32}
}
Although accumulating evidence suggests that phosphatidylinositol 3-kinase (PI3K) is a common signaling molecule for growth factor-induced amino acid uptake by the cell, the role of PI3K in the uptake of different amino acids was not tested under the same conditions. In this study, we asked whether PI3K mediates platelet-derived growth factor (PDGF) -stimulated uptake of different amino acids that are taken up through 3 major amino acid transporters expressed in rat vascular smooth muscle cells… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 32 references

Binding to the platelet-derived growth factor receptor transiently activates the p85 a-p110a phosphatidylinositide 3-kinase complex in vivo.J

J Domin, R Dhand, MD. Waterfield
Biol Chem • 1999

Cross-talk between the insulin and angiotensin signaling systems.

Proceedings of the National Academy of Sciences of the United States of America • 1996

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