Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclasts.


Phosphatidylinositol (PI)-3 kinase has been implicated in several aspects of intracellular membrane trafficking, although the detailed mechanism is yet to be established. We previously reported that wortmannin (WT), a selective inhibitor of PI-3 kinase, inhibited the bone-resorbing activity of osteoclasts (Nakamura et al., 1995, FEBS Lett., 361:79-84). In… (More)


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@article{Nakamura1997Phosphatidylinositol3KI, title={Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclasts.}, author={Itaru Nakamura and T. Sasaki and S. Tanaka and N. Takahashi and Eijiro Jimi and T. Kurokawa and Yasuyuki Kita and S{\'i}lvia Saiuli Miki Ihara and Takeshi Suda and Y. Fukui}, journal={Journal of cellular physiology}, year={1997}, volume={172 2}, pages={230-9} }