Phosphatidylinositol 3-kinase is a target for protein tyrosine nitration.

  title={Phosphatidylinositol 3-kinase is a target for protein tyrosine nitration.},
  author={Carina B Hellberg and Susan E Boggs and Eduardo G. Lapetina},
  journal={Biochemical and biophysical research communications},
  volume={252 2},
A major mechanism of injury associated with the production of nitric oxide (NO*) in vivo is due to its diffusion-limited reaction with superoxide to form peroxynitrite, which in turn may cause nitration of protein tyrosine residues. To assess the physiological role of tyrosine nitration, it is crucial to identify the proteins that become nitrated. Therefore, we treated lysates from RAW 264.7 cells with 1 mM peroxynitrite and immunoprecipitated tyrosine nitrated proteins. This treatment resulted… CONTINUE READING

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