Phosphatidylinositol 3-kinase is a key regulator of early phase differentiation in keratinocytes.

@article{Sayama2002Phosphatidylinositol3I,
  title={Phosphatidylinositol 3-kinase is a key regulator of early phase differentiation in keratinocytes.},
  author={Koji Sayama and Kenshi Yamasaki and Yasushi Hanakawa and Yuji Shirakata and Sho Tokumaru and Takeshi Ijuin and Tadaomi Takenawa and Koji Hashimoto},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 43},
  pages={
          40390-6
        }
}
The survival and growth of epithelial cells depend on adhesion to the extracellular matrix. Because epidermal keratinocytes differentiate as they leave the basement membrane, an adhesion signal may regulate the initiation of differentiation. Phosphatidylinositol 3-kinase (PI3K) is a fundamental signaling molecule that regulates the adhesion signal. Transfection of a dominant negative form of PI3K into keratinocytes using an adenovirus vector resulted in significant morphological changes… CONTINUE READING
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