Phosphatidylinositol 3-kinase interacts with the glucocorticoid receptor upon TLR2 activation

  title={Phosphatidylinositol 3-kinase interacts with the glucocorticoid receptor upon TLR2 activation},
  author={Sergio Arancibia and Dixan A Benitez and Luc{\'i}a E N{\'u}{\~n}ez and Christine M Jewell and Patricia Langjahr and Enzo Cand{\'i}a and Gerald Zapata-Torres and John Anthony Cidlowski and M. Julieta Gonz{\'a}lez and Marcela Alejandra Hermoso},
  booktitle={Journal of cellular and molecular medicine},
Airway inflammation is a common condition where glucocorticoids (GC) are a well-established therapy. It has been demonstrated that GC stimulate components of innate immunity. Specifically, GC up-regulate TLR2 expression and activation upon inflammatory stimuli; however, little is known about the signalling involved in this process. To determine the mechanism by which dexamethasone modulates TLR2-induced cytokine production this signalling pathway was monitored in a lung epithelial cell line… CONTINUE READING


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Phosphoinositide 3-kinase and akt occupy © 2011 The Authors Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing

  • D Strassheim, K Asehnoune, JS Park
  • Ltd J. Cell. Mol. Med
  • 2011
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