Phosphatidylinositol 3-kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas.

@article{Kim2004Phosphatidylinositol3I,
  title={Phosphatidylinositol 3-kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas.},
  author={Sunghoon Kim and Junghee Kang and Jingbo Qiao and Robert P. Thomas and Bernard Mark Evers and Dai H. Chung},
  journal={Journal of pediatric surgery},
  year={2004},
  volume={39 4},
  pages={516-21}
}
BACKGROUND/PURPOSE Recent findings have correlated neuroblastoma development with aberration of apoptosis. In particular, increased levels of survivin, a member of the inhibitor of apoptosis protein (IAP) family, have been associated with increased resistance to apoptosis in neuroblastomas. The purpose of this study was to determine whether the phosphatidylinositol 3-kinase (PI3K)/Akt pathway can alter the expression of survivin and facilitate tumor necrosis factor (TNF)-related apoptosis… CONTINUE READING