Phosphatidylinositol 3-kinase in angiotensin II-induced hypertrophy of vascular smooth muscle cells.

@article{Yamakawa2003Phosphatidylinositol3I,
  title={Phosphatidylinositol 3-kinase in angiotensin II-induced hypertrophy of vascular smooth muscle cells.},
  author={Tadashi Yamakawa and Shun-ichi Tanaka and Junzo Kamei and Kazuaki Kadonosono and Kenji Okuda},
  journal={European journal of pharmacology},
  year={2003},
  volume={478 1},
  pages={39-46}
}
Activation of 4E-binding protein 1 (4E-BP1) by growth factors regulates protein synthesis in vascular smooth muscle cells. The interaction between G protein-coupled receptors and activated 4E-BP1 is unclear. We examined phosphadityl inositol (PI) 3-kinase in angiotensin II-induced 4E-BP1 phosphorylation in cultured rat vascular smooth muscle cells. Angiotensin II time and dose dependently stimulated phosphorylation of 4E-BP1 through the angiotensin AT(1) receptor. Pretreatment with wortmannin… CONTINUE READING

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