Phosphatidylinositol 3-kinase functions as a Ras effector in the signaling cascade that regulates dephosphorylation of the actin-remodeling protein cofilin after costimulation of untransformed human T lymphocytes.

@article{Wabnitz2006Phosphatidylinositol3F,
  title={Phosphatidylinositol 3-kinase functions as a Ras effector in the signaling cascade that regulates dephosphorylation of the actin-remodeling protein cofilin after costimulation of untransformed human T lymphocytes.},
  author={Guido H Wabnitz and Gabriele Nebl and Martin Klemke and Andreas J Schr{\"o}der and Yvonne Samstag},
  journal={Journal of immunology},
  year={2006},
  volume={176 3},
  pages={1668-74}
}
The activity of cofilin, an actin-remodeling protein, is required for T lymphocyte activation with regard to formation of the immunological synapse, cytokine production, and proliferation. In unstimulated T PBL (PB-T), cofilin is present in its Ser3-phosphorylated inactive form. Costimulation of TCR/CD3 and CD28 induces dephosphorylation and, thus… CONTINUE READING