Phosphatidylinositol-3-kinase activity during in vitro dendritic cell generation determines suppressive or stimulatory capacity

@article{Caro2011Phosphatidylinositol3kinaseAD,
  title={Phosphatidylinositol-3-kinase activity during in vitro dendritic cell generation determines suppressive or stimulatory capacity},
  author={Valentina Di Caro and Antonella D’Anneo and Brett Michael Phillips and Carl L Engman and J. B. Harnaha and M. Alejandra Trucco and Nick Giannoukakis},
  journal={Immunologic Research},
  year={2011},
  volume={50},
  pages={130-152}
}
Modulating PI3K at different stages of dendritic cells (DC) generation could be a novel means to balance the generation of immunosuppressive versus immunostimulatory DC. We show that PI3K inhibition during mouse DC generation in vitro results in cells that are potently immunosuppressive and characteristic of CD8alpha− CD11c+ CD11b+ DC. These DC exhibited low surface class I and class II MHC, CD40, and CD86 and did not produce TNF-alpha. In allogeneic MLR, these DC were suppressive. Although in… CONTINUE READING
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