Phosphatidylinositol-3-kinase activation blocks amyloid beta-induced neurotoxicity.

@article{Lee2008Phosphatidylinositol3kinaseAB,
  title={Phosphatidylinositol-3-kinase activation blocks amyloid beta-induced neurotoxicity.},
  author={Kyu-Yong Lee and S R Koh and Min Young Noh and Seung Hyun Kim and Young Joo Lee},
  journal={Toxicology},
  year={2008},
  volume={243 1-2},
  pages={43-50}
}
The phosphatidylinositol-3-kinase (PI3-K) pathway has been suggested to play a pivotal role in neuronal survival. Although PI3-K has been recently identified as a neuroprotectant, there are no reports regarding the effect of a direct PI3-K activator on Abeta-induced neurotoxicity. We investigated whether direct PI3-K activation prevents Abeta-induced neurotoxicity. To evaluate the effect of Abeta on neuronal cells, we treated primary cultured cortical neurons with several doses of Abeta for 72… CONTINUE READING