Phosphatidylinositol 3-kinase Inhibitor (PIK75) Containing Surface Functionalized Nanoemulsion for Enhanced Drug Delivery, Cytotoxicity and Pro-apoptotic Activity in Ovarian Cancer Cells

@article{Talekar2012Phosphatidylinositol3I,
  title={Phosphatidylinositol 3-kinase Inhibitor (PIK75) Containing Surface Functionalized Nanoemulsion for Enhanced Drug Delivery, Cytotoxicity and Pro-apoptotic Activity in Ovarian Cancer Cells},
  author={Meghna Talekar and Srinivas Ganta and Amit Singh and Mansoor M Amiji and Jackie Kendall and William A. Denny and Sanjay Garg},
  journal={Pharmaceutical Research},
  year={2012},
  volume={29},
  pages={2874-2886}
}
Ovarian cancer is a debilitating disease, which needs multi-pronged approach of targeted drug delivery and enhanced efficacy with the use of combination therapeutics. In this study, we have examined the anticancer activity of PIK75 incorporated in surface functionalized nanoemulsions for targeted delivery to SKOV-3 cells. A pro-apoptotic molecule C6-ceramide was also co-delivered to augment therapeutic efficacy. EGFR and FR functionalized nanoemulsions incorporating PIK75 and C6-ceramide were… CONTINUE READING
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