Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer

  title={Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer},
  author={Margaret A Knowles and Fiona M. Platt and Rebecca L. Ross and Carolyn D. Hurst},
  journal={Cancer Metastasis Reviews},
  pages={305 - 316}
The phosphatidylinositol 3-kinase (PI3K) pathway is a critical signal transduction pathway that regulates multiple cellular functions. Aberrant activation of this pathway has been identified in a wide range of cancers. Several pathway components including AKT, PI3K and mTOR represent potential therapeutic targets and many small molecule inhibitors are in development or early clinical trials. The complex regulation of the pathway, together with the multiple mechanisms by which it can be… CONTINUE READING

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