Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation

  title={Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation},
  author={Makoto Mizuno and Kazuyuki Yamada and Nobuyuki Takei and Manh Hung Tran and J He and Akira Nakajima and Hiroyuki Nawa and Toshitaka Nabeshima},
  journal={Molecular Psychiatry},
Brain-derived neurotrophic factor (BDNF) plays a critical role in synaptic plasticity such as long-term potentiation (LTP), a form of synaptic correlate of learning and memory. BDNF is also implicated in learning and memory. We have demonstrated that radial arm maze training in rats for spatial learning and memory results in a significant increase in the BDNF mRNA expression in the hippocampus. Moreover, antisense BDNF oligonucleotide treatment impaired not only acquisition, but also… CONTINUE READING


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