Phosphatidylinositol 3-kinase/Akt signaling pathway mediates acupuncture-induced dopaminergic neuron protection and motor function improvement in a mouse model of Parkinson's disease.

@article{Kim2011Phosphatidylinositol3S,
  title={Phosphatidylinositol 3-kinase/Akt signaling pathway mediates acupuncture-induced dopaminergic neuron protection and motor function improvement in a mouse model of Parkinson's disease.},
  author={Seung-Nam Kim and Seung-Tae Kim and A. Doo and Ji-Yeun Park and Woongjoon Moon and Younbyoung Chae and Chang Shik Yin and Hyejung Lee and Hi-Joon Park},
  journal={The International journal of neuroscience},
  year={2011},
  volume={121 10},
  pages={562-9}
}
It has been reported that acupuncture treatment reduced dopaminergic neuron degeneration in Parkinson's disease (PD) models. However, the mechanistic pathways underlying, such neuroprotection, are poorly understood. Here, we investigated the effects and the underlying mechanism of acupuncture in a mouse model of PD using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). First, we observed that MPTP-induced impairment of Akt activation, but not MPTP-induced c-Jun activation, was effectively… CONTINUE READING

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