Phosphatidylinositol 3-kinase, a novel target molecule for the inhibitory effects of kaempferol on neoplastic cell transformation.

@article{Lee2010Phosphatidylinositol3A,
  title={Phosphatidylinositol 3-kinase, a novel target molecule for the inhibitory effects of kaempferol on neoplastic cell transformation.},
  author={Kyung Mi Lee and Dong Eun Lee and Sang Kwon Seo and Mun Kyung Hwang and Yong-Seok Heo and Ki Won Lee and Hyong Joo Lee},
  journal={Carcinogenesis},
  year={2010},
  volume={31 8},
  pages={
          1338-43
        }
}
Kaempferol (KF), which is a natural dietary flavonoid, has potential beneficial effects as a chemopreventive agent for critical health conditions, such as cancer. However, the molecular mechanisms underlying the activity of KF remain unknown. We report on the inhibition of neoplastic cell transformation by KF through the suppression of phosphatidylinositol 3-kinase (PI3K) activity. Epidermal growth factor (EGF)-induced neoplastic transformation of mouse epidermal JB6 P+ cells was inhibited by… CONTINUE READING
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