Phosphatidylinositol 3-Kinase Signaling through Protein Kinase C Induces NADPH Oxidase-mediated Oxidant Generation and NF-B Activation in Endothelial Cells *

@inproceedings{Frey2006Phosphatidylinositol3S,
  title={Phosphatidylinositol 3-Kinase Signaling through Protein Kinase C Induces NADPH Oxidase-mediated Oxidant Generation and NF-B Activation in Endothelial Cells *},
  author={Randall S. Frey and Xiaopei Gao and Kamran Javaid and Shahid S. Siddiqui and Arshad Rahman and Asrar B. Malik},
  year={2006}
}
We addressed the role of class 1B phosphatidylinositol 3-kinase (PI3K) isoform PI3K in mediating NADPH oxidase activation and reactive oxidant species (ROS) generation in endothelial cells (ECs) and of PI3K -mediated oxidant signaling in the mechanism of NFB activation and intercellular adhesion molecule (ICAM)-1 expression. We used lung microvascular ECs… CONTINUE READING