Phosphatidylinositol 3-Akt-kinase-dependent phosphorylation of p21(Waf1/Cip1) as a novel mechanism of neuroprotection by glucocorticoids.

@article{Harms2007Phosphatidylinositol3P,
  title={Phosphatidylinositol 3-Akt-kinase-dependent phosphorylation of p21(Waf1/Cip1) as a novel mechanism of neuroprotection by glucocorticoids.},
  author={Christoph Harms and Katharina Albrecht and Ulrike Harms and Kerstin Seidel and Ludger Hauck and Tina Baldinger and Denise H{\"u}bner and Golo Kronenberg and Junfeng An and Karsten Ruscher and Andreas Meisel and Ulrich Dirnagl and R{\"u}diger von Harsdorf and Matthias Endres and Heide Hoertnagl},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 17},
  pages={4562-71}
}
The role of glucocorticoids in the regulation of apoptosis remains incongruous. Here, we demonstrate that corticosterone protects neurons from apoptosis by a mechanism involving the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). In primary cortical neurons, corticosterone leads to a dose- and Akt-kinase-dependent upregulation with enhanced phosphorylation and cytoplasmic appearance of p21(Waf1/Cip1) at Thr 145. Exposure of neurons to the neurotoxin ethylcholine aziridinium (AF64A) results in… CONTINUE READING

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