Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 regulates epinephrine-induced exocytosis of Weibel-Palade bodies.

@article{Hooren2014Phosphatidylinositol345triphosphate,
  title={Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 regulates epinephrine-induced exocytosis of Weibel-Palade bodies.},
  author={Kathinka W. E. M. van Hooren and Dorothee van Breevoort and Mar Fernandez-Borja and Alexander Benjamin Meijer and J Eikenboom and Ruben Bierings and Jan Voorberg},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2014},
  volume={12 2},
  pages={
          273-81
        }
}
BACKGROUND Weibel-Palade bodies (WPBs) function as storage vesicles for von Willebrand factor (VWF) and a number of other bioactive compounds, including angiopoietin-2 and insulin-like growth factor-binding protein 7. WPBs release their content following stimulation with agonists that increase the level of intracellular Ca²⁺, such as thrombin, or agonists that increase intracellular levels of cAMP, such as epinephrine. OBJECTIVE Previously, we have shown that the exchange protein activated by… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

Rap1-Rac1 circuits potentiate platelet activation.

  • Arteriosclerosis, thrombosis, and vascular biology
  • 2012

cell-specific Weibel-Palade bodies

EL Doyle, V Ridger, +3 authors DF. Cutler
  • J Proteome Res
  • 2012

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