Phosphatidylinositol-3' kinase-dependent vesicle formation in macrophages in response to macrophage colony stimulating factor.

@article{Murray2000Phosphatidylinositol3KV,
  title={Phosphatidylinositol-3' kinase-dependent vesicle formation in macrophages in response to macrophage colony stimulating factor.},
  author={Joseph J. Murray and Lynn O. Wilson and Stuart Kellie},
  journal={Journal of cell science},
  year={2000},
  volume={113 Pt 2},
  pages={337-48}
}
Treatment of the BAC1.2F5 macrophage cell line with Macrophage Colony Stimulating Factor (M-CSF) resulted in a rapid induction of vesiculation that was reminiscent of macropinocytosis. Time-lapse micrography showed that these vesicles initiated as small vesicles at the cell periphery, but grew in size and migrated with time to a perinuclear localisation after growth factor stimulation. Immunofluorescence showed that the M-CSF receptor (c-fms) associated with the small vesicles and also the… CONTINUE READING
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