Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation

  title={Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation},
  author={Y. Qin and Flora Ting and M. J. Kim and J. Strelnikov and J. Harmon and F. Gao and Andr{\'e}a C. Dos{\'e} and Babie Teng and M. Alipour and Z. Yao and R. Crooke and R. Krauss and M. Medina},
  booktitle={Arteriosclerosis, thrombosis, and vascular biology},
  • Y. Qin, Flora Ting, +10 authors M. Medina
  • Published in
    Arteriosclerosis, thrombosis…
  • Chemistry, Medicine
  • Supplemental Digital Content is available in the text. Objective: TMEM55B (transmembrane protein 55B) is a phosphatidylinositol-(4,5)-bisphosphate (PI[4,5]P2) phosphatase that regulates cellular cholesterol, modulates LDLR (low-density lipoprotein receptor) decay, and lysosome function. We tested the effects of Tmem55b knockdown on plasma lipids in mice and assessed the roles of LDLR lysosomal degradation and change in (PI[4,5]P2) in mediating these effects. Approach and Results: Western diet… CONTINUE READING


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