Phosphatidylethanolamine methylation and hepatoma cell growth.

  title={Phosphatidylethanolamine methylation and hepatoma cell growth.},
  author={Dennis E. Vance and Martin Houweling and M Lee and Zheng Lie Cui},
  journal={Anticancer research},
  volume={16 3B},
Phosphatidylethanolamine is converted to phosphatidylcholine in hepatocytes via the enzyme phosphatidylethanolamine N-methyltransferase (PEMT). An isoform, PEMT2 has been cloned, expressed and localized to a mitochondria-associated membrane in rat liver. Expression of PEMT2 caused a decreased rate of cell division of cultured rat hepatoma cells. Mechanistic studies suggest that the slower growth of transfected hepatoma cells may be due to down regulation of CTP: phosphocholine… CONTINUE READING