Phosphatidylethanolamine from Phosphatidylserine Decarboxylase2 is Essential for Autophagy Under Cadmium Stress in Saccharomyces cerevisiae

@article{Muthukumar2013PhosphatidylethanolamineFP,
  title={Phosphatidylethanolamine from Phosphatidylserine Decarboxylase2 is Essential for Autophagy Under Cadmium Stress in Saccharomyces cerevisiae},
  author={Kannan Muthukumar and Vasanthi Nachiappan},
  journal={Cell Biochemistry and Biophysics},
  year={2013},
  volume={67},
  pages={1353-1363}
}
Cadmium (Cd) is a potent toxic element used in several industries and in the process contaminates air, soil, and water. Exposure of Saccharomyces cerevisiae to Cd increases the major phospholipids, and profound increase was observed in phosphatidylethanolamine (PE). In yeast, there are four different pathways contributing to the biosynthesis of PE, and contribution to PE pool through phosphatidylserine decarboxylase2 (psd2) is not significant in normal conditions. Upon Cd exposure, psd2Δ strain… 
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Phosphatidylethanolamine positively regulates autophagy and longevity
TLDR
It is shown that the abundance of phosphatidylethanolamine positively regulates autophagy and that organismal life or healthspan could be positively influenced by the consumption of ethanolamine-rich food.
Lipid droplets alleviate cadmium induced cytotoxicity in Saccharomyces cerevisiae.
TLDR
The possible metabolic link between LDs and oxidative stress in S. cerevisiae is revealed and the over expression of DGA1 and LRO1 rescued the Cd induced cytotoxicity by enhancing the formation of LDs.
Endoplasmic reticulum stress affects the transport of phosphatidylethanolamine from mitochondria to the endoplasmic reticulum in S.cerevisiae.
Effect of cadmium on essential metals and their impact on lipid metabolism in Saccharomyces cerevisiae
TLDR
The impact of Cd interference on the essential minerals such as Zn and Ca and their influence on endoplasmic reticulum stress and lipid metabolism of budding yeast is explored.
Dolichyl pyrophosphate phosphatase-mediated N-glycosylation defect dysregulates lipid homeostasis in Saccharomyces cerevisiae.
Transport of Phosphatidylserine from the Endoplasmic Reticulum to the Site of Phosphatidylserine Decarboxylase2 in Yeast
TLDR
The emerging picture of the Psd2p‐specific transport pathway is one in which the enzyme and its non‐catalytic N‐terminal domains act as a hub to nucleate the assembly of a multiprotein complex, which facilitates PtdSer transport at membrane contact sites between the ER and Golgi/endosome membranes.
Autophagy Improves ARA-Rich TAG Accumulation in Mortierella alpina by Regulating Resource Allocation
TLDR
This study proves that regulation of cell autophagy through the MAatg8-PE conjugation system-related gene overexpression or exogenous supply of ethanolamine would be an efficient strategy to increase and maintain biomass productivity when high TAG content is obtained under nitrogen deficiency, which could be useful for the development of new strategies that will achieve more biomass and maximal lipid productivity.
Regulation of autophagy by mitochondrial phospholipids in health and diseases.
  • Paul Hsu, Yuguang Shi
  • Biology, Medicine
    Biochimica et biophysica acta. Molecular and cell biology of lipids
  • 2017
Molecular Biology of Cadmium Toxicity in Saccharomyces cerevisiae
TLDR
An attempt has been made to evaluate published cellular and molecular toxicity data related to Cd stress, and specifically published on S. cerevisiae, an eukaryotic unicellular model organism.
Cell biology, physiology and enzymology of phosphatidylserine decarboxylase.
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