Phosphatidylethanolamine enhances amyloid fiber-dependent membrane fragmentation.

@article{Sciacca2012PhosphatidylethanolamineEA,
  title={Phosphatidylethanolamine enhances amyloid fiber-dependent membrane fragmentation.},
  author={Michele Francesco Maria Sciacca and Jeffrey R. Brender and Dong-kuk Lee and Ayyalusamy Ramamoorthy},
  journal={Biochemistry},
  year={2012},
  volume={51 39},
  pages={7676-84}
}
The toxicity of amyloid-forming peptides has been hypothesized to reside in the ability of protein oligomers to interact with and disrupt the cell membrane. Much of the evidence for this hypothesis comes from in vitro experiments using model membranes. However, the accuracy of this approach depends on the ability of the model membrane to accurately mimic the cell membrane. The effect of membrane composition has been overlooked in many studies of amyloid toxicity in model systems. By combining… CONTINUE READING

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