Phosphatidylethanolamine critically supports internalization of cell-penetrating protein C inhibitor

@article{Baumgrtner2007PhosphatidylethanolamineCS,
  title={Phosphatidylethanolamine critically supports internalization of cell-penetrating protein C inhibitor},
  author={Petra Baumg{\"a}rtner and Margarethe Geiger and Susanne Zieseniss and Julia Malleier and James Andrew Huntington and Karin Hochrainer and Edith Bielek and Mechthild Stoeckelhuber and Kirsten Lauber and Dag Scherfeld and Petra Schwille and Katja W{\"a}ldele and Klaus Dr Ing Beyer and Bernd Engelmann},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={179},
  pages={793 - 804}
}
Although their contribution remains unclear, lipids may facilitate noncanonical routes of protein internalization into cells such as those used by cell-penetrating proteins. We show that protein C inhibitor (PCI), a serine protease inhibitor (serpin), rapidly transverses the plasma membrane, which persists at low temperatures and enables its nuclear targeting in vitro and in vivo. Cell membrane translocation of PCI necessarily requires phosphatidylethanolamine (PE). In parallel, PCI acts as a… CONTINUE READING

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