Phosphatidylcholine-specific phospholipase C and sphingomyelinase activities in bacteria of the Bacillus cereus group.

@article{Pomerantsev2003PhosphatidylcholinespecificPC,
  title={Phosphatidylcholine-specific phospholipase C and sphingomyelinase activities in bacteria of the Bacillus cereus group.},
  author={Andrei P. Pomerantsev and K V Kalnin and Manuel Osorio and Stephen H Leppla},
  journal={Infection and immunity},
  year={2003},
  volume={71 11},
  pages={6591-606}
}
Bacillus anthracis is nonhemolytic, even though it is closely related to the highly hemolytic Bacillus cereus. Hemolysis by B. cereus results largely from the action of phosphatidylcholine-specific phospholipase C (PC-PLC) and sphingomyelinase (SPH), encoded by the plc and sph genes, respectively. In B. cereus, these genes are organized in an operon regulated by the global regulator PlcR. B. anthracis contains a highly similar cereolysin operon, but it is transcriptionally silent because the B… CONTINUE READING
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