Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model

@inproceedings{Sovadinov2015PhosphatidylcholineSP,
  title={Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model},
  author={Iva Sovadinov{\'a} and Pavel Babica and Hatice B{\"o}ke and E. Samjeeva Kumar and Andrew Wilke and Joon-Suk Park and James Edward Trosko and Brad L. Upham and Rajesh Agarwal},
  booktitle={PloS one},
  year={2015}
}
UNLABELLED Dysregulation of gap junctional intercellular communication (GJIC) has been associated with different pathologies, including cancer; however, molecular mechanisms regulating GJIC are not fully understood. Mitogen Activated Protein Kinase (MAPK)-dependent mechanisms of GJIC-dysregulation have been well-established, however recent discoveries have implicated phosphatidylcholine-specific phospholipase C (PC-PLC) in the regulation of GJIC. What is not known is how prevalent these two… CONTINUE READING

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