Phosphatidic acid phosphatase from mammalian tissues: discovery of channel-like proteins with unexpected functions.

@article{Kanoh1997PhosphatidicAP,
  title={Phosphatidic acid phosphatase from mammalian tissues: discovery of channel-like proteins with unexpected functions.},
  author={Hiroyuki Kanoh and M D Hiroshi Kai and Ikuo Wada},
  journal={Biochimica et biophysica acta},
  year={1997},
  volume={1348 1-2},
  pages={
          56-62
        }
}
Phosphatidic acid phosphatase (PAP) has long been known as a key enzyme involved in both glycerolipid biosynthesis and cellular signal transduction. The cDNA cloning of a plasma membrane-bound type 2 PAP has revealed the existence of a novel glycoprotein with six transmembrane domains. The type 2 PAP now represents an enzyme family consisting of Drosophila Wunen and rat Dri 42, which participate in germ cell migration and epithelial differentiation, respectively. Such novel functions of the… CONTINUE READING
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