Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism.


Recognition of lipids by proteins is important for their targeting and activation in many signaling pathways, but the mechanisms that regulate such interactions are largely unknown. Here, we found that binding of proteins to the ubiquitous signaling lipid phosphatidic acid (PA) depended on intracellular pH and the protonation state of its phosphate headgroup. In yeast, a rapid decrease in intracellular pH in response to glucose starvation regulated binding of PA to a transcription factor, Opi1, that coordinately repressed phospholipid metabolic genes. This enabled coupling of membrane biogenesis to nutrient availability.

DOI: 10.1126/science.1191026

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@article{Young2010PhosphatidicAI, title={Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism.}, author={Barry P. Young and John J H Shin and Rick Orij and Jesse Tzu-Cheng Chao and Shu - Chen Li and Xue Li Guan and Anthony Khong and E. E. Jan and Markus R. Wenk and William A Prinz and Gertien J Smits and Christopher J. R. Loewen}, journal={Science}, year={2010}, volume={329 5995}, pages={1085-8} }