Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism.

Abstract

Recognition of lipids by proteins is important for their targeting and activation in many signaling pathways, but the mechanisms that regulate such interactions are largely unknown. Here, we found that binding of proteins to the ubiquitous signaling lipid phosphatidic acid (PA) depended on intracellular pH and the protonation state of its phosphate headgroup. In yeast, a rapid decrease in intracellular pH in response to glucose starvation regulated binding of PA to a transcription factor, Opi1, that coordinately repressed phospholipid metabolic genes. This enabled coupling of membrane biogenesis to nutrient availability.

DOI: 10.1126/science.1191026

4 Figures and Tables

05010015020102011201220132014201520162017
Citations per Year

412 Citations

Semantic Scholar estimates that this publication has 412 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Young2010PhosphatidicAI, title={Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism.}, author={Barry P. Young and John J H Shin and Rick Orij and Jesse Tzu-Cheng Chao and Shu - Chen Li and Xue Li Guan and Anthony Khong and E. E. Jan and Markus R. Wenk and William A Prinz and Gertien J Smits and Christopher J. R. Loewen}, journal={Science}, year={2010}, volume={329 5995}, pages={1085-8} }