Phosphatidic acid-induced translocation of cytosolic components in a cell-free system of NADPH oxidase: mechanism of activation and effect of diacylglycerol.

@article{Park1996PhosphatidicAT,
  title={Phosphatidic acid-induced translocation of cytosolic components in a cell-free system of NADPH oxidase: mechanism of activation and effect of diacylglycerol.},
  author={J. Park},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={229 3},
  pages={
          758-63
        }
}
  • J. Park
  • Published 1996
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
The translocation of the cytosolic components p47(phox) and p67(phox) to the plasma membrane and O-2 generation of the NADPH oxidase from human neutrophils can be elicited with phosphatidic acid (PA) in the cell-free system. In the presence of guanosine 5'-O-(3-thiotriphosphate) (GTPgammaS), the activation of oxidase by PA was concentration-dependent. Diacyglycerol (DG) acted synergistically with PA in both translocation and O-2 production. In addition, the present results suggest that the… Expand
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