Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties.

@article{Putta2016PhosphatidicAB,
  title={Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties.},
  author={Priya Putta and Johanna Rankenberg and Ruud A. Korver and Ringo van Wijk and Teun Munnik and Christa Testerink and Edgar Eduard Kooijman},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1858 11},
  pages={2709-2716}
}
Phosphatidic acid (PA) is a crucial membrane phospholipid involved in de novo lipid synthesis and numerous intracellular signaling cascades. The signaling function of PA is mediated by peripheral membrane proteins that specifically recognize PA. While numerous PA-binding proteins are known, much less is known about what drives specificity of PA-protein binding. Previously, we have described the ionization properties of PA, summarized in the electrostatic-hydrogen bond switch, as one aspect that… CONTINUE READING
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