Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics.

  title={Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics.},
  author={Takashi Baba and Yuriko Kashiwagi and Nagisa Arimitsu and Takeshi Kogure and Ayumi Edo and Tomohiro Maruyama and Kazuki Nakao and Hiroki Nakanishi and Makoto Kinoshita and Michael A. Frohman and Akitsugu Yamamoto and Katsuko Tani},
  journal={The Journal of biological chemistry},
  volume={289 16},
Recent studies have suggested that phosphatidic acid (PA), a cone-shaped phospholipid that can generate negative curvature of lipid membranes, participates in mitochondrial fusion. However, precise mechanisms underling the production and consumption of PA on the mitochondrial surface are not fully understood. Phosphatidic acid-preferring phospholipase A1 (PA-PLA1)/DDHD1 is the first identified intracellular phospholipase A1 and preferentially hydrolyzes PA in vitro. Its cellular and… CONTINUE READING