Phosphate transporters of the SLC20 and SLC34 families.

  title={Phosphate transporters of the SLC20 and SLC34 families.},
  author={Ian Cameron Forster and Nati Hernando and Juerg Biber and Heini Murer},
  journal={Molecular aspects of medicine},
  volume={34 2-3},
Transport of inorganic phosphate (Pi) across the plasma membrane is essential for normal cellular function. Members of two families of SLC proteins (SLC20 and SLC34) act as Na(+)-dependent, secondary-active cotransporters to transport Pi across cell membranes. The SLC34 proteins are expressed in specific organs important for Pi homeostasis: NaPi-IIa (SLC34A1) and NaPi-IIc (SLC34A3) fulfill essential roles in Pi reabsorption in the kidney proximal tubule and NaPi-IIb (SLC34A2) mediates Pi… CONTINUE READING


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