Phosphate transporters: a tale of two solute carrier families.

  title={Phosphate transporters: a tale of two solute carrier families.},
  author={Leila V. Virkki and Juerg Biber and Heini Murer and Ian Cameron Forster},
  journal={American journal of physiology. Renal physiology},
  volume={293 3},
Phosphate is an essential component of life and must be actively transported into cells against its electrochemical gradient. In vertebrates, two unrelated families of Na+ -dependent P(i) transporters carry out this task. Remarkably, the two families transport different P(i) species: whereas type II Na+/P(i) cotransporters (SCL34) prefer divalent HPO(4)(2-), type III Na(+)/P(i) cotransporters (SLC20) transport monovalent H2PO(4)(-). The SCL34 family comprises both electrogenic and… CONTINUE READING
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