Phosphate is a specific signal for induction of osteopontin gene expression.

@article{Beck2000PhosphateIA,
  title={Phosphate is a specific signal for induction of osteopontin gene expression.},
  author={George R Beck and Brad Zerler and Elizabeth Moran},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 15},
  pages={8352-7}
}
Osteopontin is a phosphorylated glycoprotein secreted to the mineralizing extracellular matrix by osteoblasts during bone development. It is believed to facilitate the attachment of osteoblasts and osteoclasts to the extracellular matrix, allowing them to perform their respective functions during osteogenesis. Several other functions have been suggested for this protein, and its up-regulation is associated with various disease states related to calcification, including arterial plaque formation… CONTINUE READING
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Human Tumor Viruses, ed

G. R. Beck, Jr., B. Zerler, E. Moran
McCance, D. J. (Am. Soc. Microbiol., • 1998

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