Phosphate is a specific signal for ATDC5 chondrocyte maturation and apoptosis-associated mineralization: possible implication of apoptosis in the regulation of endochondral ossification.

@article{Magne2003PhosphateIA,
  title={Phosphate is a specific signal for ATDC5 chondrocyte maturation and apoptosis-associated mineralization: possible implication of apoptosis in the regulation of endochondral ossification.},
  author={David Magne and Gilles Bluteau and Corrine Faucheux and Gaby Palmer and Caroline Vignes-Colombeix and Paul Pilet and Thierry Rouillon and Joseph Caverzasio and Pierre Weiss and Guy Daculsi and J{\'e}r{\^o}me Guicheux},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2003},
  volume={18 8},
  pages={1430-42}
}
UNLABELLED Involvement of Pi and Ca in chondrocyte maturation was studied because their levels increase in cartilage growth plate. In vitro results showed that Pi increases type X collagen expression, and together with Ca, induces apoptosis-associated mineralization, which is similar to that analyzed in vivo, thus suggesting a role for both ions and apoptosis during endochondral ossification. INTRODUCTION During endochondral ossification, regulation of chondrocyte maturation governs the… CONTINUE READING

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