Phosphate-induced efflux of adenine nucleotides from heart mitochondria.

  title={Phosphate-induced efflux of adenine nucleotides from heart mitochondria.},
  author={Gregory K Asimakis and Vincent R. Conti},
  journal={The American journal of physiology},
  volume={249 5 Pt 2},
Adenine nucleotide efflux from isolated rat heart mitochondria was studied. Inorganic phosphate induced efflux of adenine nucleotides from the mitochondria. This efflux was inhibited by carboxyatractyloside and atractyloside. The rate of efflux showed saturation kinetics with respect to extramitochondrial phosphate (Km, 9.5 mM). Lowering the pH from 7.4 to 6.8 had little or no effect on the rate of efflux. Deenergizing the mitochondria enhanced carboxyatractyloside-insensitive efflux, but it… CONTINUE READING

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