Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motor neuron disease and controls.

@article{Schmidt1987PhosphateDA,
  title={Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motor neuron disease and controls.},
  author={Marie Luise Schmidt and Martin J. Carden and V M.-Y. Lee and John Q. Trojanowski},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1987},
  volume={56 3},
  pages={282-94}
}
Axonal accumulations of neurofilaments (NFs) may result from abnormalities intrinsic to NF subunits (e.g., proteolytic cleavage, altered phosphorylation), or from abnormalities extrinsic to NFs that retard the transport of these neuron-specific intermediate filaments. To evaluate this hypothesis, we probed the NF-rich axonal swellings seen in normal spinal cords, "globules", and the larger ones, "spheroids", seen in the spinal cords of patients with motor neuron disease by using a library of… CONTINUE READING