Phosphate binders affect vitamin K concentration by undesired binding, an in vitro study

@inproceedings{Neradova2017PhosphateBA,
  title={Phosphate binders affect vitamin K concentration by undesired binding, an in vitro study},
  author={Aegida Neradova and Stefan P Schumacher and Isabelle Hubeek and Petra Lux and Leon J Schurgers and Marc G Vervloet},
  booktitle={BMC nephrology},
  year={2017}
}
BACKGROUND Vascular calcification is a major contributing factor to mortality in end stage renal disease (ESRD). Despite the efficacy of phosphate binders to improve hyperphosphatemia, data on vascular calcification are less clear. There seems to be a difference in attenuation or delay in progression between different binders. In this in vitro experiment we tested whether phosphate binders could limit bioavailability of vitamin K2 by undesired binding. Vitamin K-deficiency limits activation of… CONTINUE READING
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