Phosphate Regulates Osteopontin Gene Transcription

  title={Phosphate Regulates Osteopontin Gene Transcription},
  author={S. Fatherazi and D. Matsa-Dunn and B. Foster and R. Rutherford and M. Somerman and R. Presland},
  journal={Journal of Dental Research},
  pages={39 - 44}
  • S. Fatherazi, D. Matsa-Dunn, +3 authors R. Presland
  • Published 2009
  • Medicine, Biology
  • Journal of Dental Research
  • Extracellular inorganic phosphate (ePi) is a key regulator of cementoblast behavior, both in vivo and in vitro, and results in a marked increase in osteopontin expression in vitro. To examine the molecular mechanisms involved in ePi induction of osteopontin gene expression, we transfected a series of osteopontin promoter-luciferase constructs into OCCM-30 cementoblasts. Our results demonstrate that ePi can directly induce osteopontin gene transcription. The region responsive to ePi signaling… CONTINUE READING
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