Phosphate Analogs Block Adaptation in Hair Cells by Inhibiting Adaptation-Motor Force Production

@article{Yamoah1996PhosphateAB,
  title={Phosphate Analogs Block Adaptation in Hair Cells by Inhibiting Adaptation-Motor Force Production},
  author={Ebenezer N. Yamoah and Peter G. Gillespie},
  journal={Neuron},
  year={1996},
  volume={17},
  pages={523-533}
}
To ensure optimal sensitivity for mechanoelectrical transduction, hair cells adapt to prolonged stimuli using active motors. Adaptation motors are thought to employ myosin molecules as their force-producing components. We find that beryllium fluoride, vanadate, and sulfate, phosphate analogs that inhibit the ATPase activity of myosin, inhibit adaptation by abolishing motor force production. Phosphate analogs interact with a 120-kDa bundle protein, most likely myosin 1 beta, in a manner that… CONTINUE READING

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