Phosphatase is responsible for run down, and probably G protein- mediated inhibition of inwardly rectifying K+ currents in guinea pig chromaffin cells

@article{Inoue1995PhosphataseIR,
  title={Phosphatase is responsible for run down, and probably G protein- mediated inhibition of inwardly rectifying K+ currents in guinea pig chromaffin cells},
  author={M Inoue and I Imanaga},
  journal={The Journal of General Physiology},
  year={1995},
  volume={105},
  pages={249 - 266}
}
  • M Inoue, I Imanaga
  • Published 1995 in The Journal of general physiology
The mechanism of G protein-mediated inhibition of an inwardly rectifying K+ current (IIR) in adrenal chromaffin cells was investigated using the whole-cell version of the patch clamp technique. In case of recording with use of ATP-containing patch solution, the IIR was well maintained; otherwise, it ran down within 15 min. This run down was not prevented by replacement with adenylyl-imidodiphosphate, a nonhydrolysable analogue of ATP, but was markedly reduced by the addition to the ATP-free… CONTINUE READING

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