Phosphatase inhibition potentiates IL-6 production by mast cells in response to FcepsilonRI-mediated activation: involvement of p38 MAPK.

@article{Boudreau2004PhosphataseIP,
  title={Phosphatase inhibition potentiates IL-6 production by mast cells in response to FcepsilonRI-mediated activation: involvement of p38 MAPK.},
  author={Robert T.M. Boudreau and David W. Hoskin and Tong-Jun Lin},
  journal={Journal of leukocyte biology},
  year={2004},
  volume={76 5},
  pages={
          1075-81
        }
}
  • Robert T.M. Boudreau, David W. Hoskin, Tong-Jun Lin
  • Published in Journal of leukocyte biology 2004
  • Biology, Medicine
  • Mast cells are crucial effector cells in the immune response through mediator secretion and release of cytokines. A coordinated balance between protein kinases and phosphatases plays an essential role in the regulation of mast cell mediator secretion. We have previously shown that treatment of mast cells with okadaic acid (OA), a protein phosphatase 2A (PP2A) inhibitor, results in a dose-dependent increase in interleukin (IL)-6 production. We show here for the first time a synergism between OA… CONTINUE READING

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