Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis?

@article{Ioffe2012PhosphataseAT,
  title={Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis?},
  author={Yevgeniya Jane Mikhailovna Ioffe and Katherine B. Chiappinelli and David G. Mutch and Israel Zighelboim and Paul J Goodfellow},
  journal={Gynecologic oncology},
  year={2012},
  volume={124 2},
  pages={340-6}
}
OBJECTIVES The PTEN pseudogene, PTENP1, was recently shown to play a role in cell proliferation in a prostate cancer model. In the present study, we sought to determine whether PTENP1 is expressed in endometrial cancer (EMCA) cell lines and primary tumors along with the microRNAs (miRNAs) that are predicted to regulate PTEN and PTENP1 transcript levels. METHODS RNA was prepared from six EMCA cell lines, three normal endometrial samples, and 61 primary tumors. TaqMan® RT-PCR was used to… CONTINUE READING
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