Phosphatase activity, trimerization, and the C-terminal polybasic region are all required for PRL1-mediated cell growth and migration.

@article{Sun2007PhosphataseAT,
  title={Phosphatase activity, trimerization, and the C-terminal polybasic region are all required for PRL1-mediated cell growth and migration.},
  author={Jin-peng Sun and Yong Luo and Xiao Yu and Wei-qing Wang and Bo Zhou and Fubo Liang and Zhong-Yin Zhang},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 39},
  pages={29043-51}
}
The phosphatase of regenerating liver (PRL) phosphatases are implicated in a number of tumorigenesis and metastasis processes. The PRLs are unique among protein-tyrosine phosphatases in that they have extremely low phosphatase activity, a high propensity for trimer formation, and a polybasic region that precedes the C-terminal prenylation motif. To investigate the functional significance of these distinctive biochemical and structural features, we established a cell-based system in which… CONTINUE READING
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