Phosphatase Rtr1 Regulates Global Levels of Serine 5 RNA Polymerase II C-Terminal Domain Phosphorylation and Cotranscriptional Histone Methylation.

@article{Hunter2016PhosphataseRR,
  title={Phosphatase Rtr1 Regulates Global Levels of Serine 5 RNA Polymerase II C-Terminal Domain Phosphorylation and Cotranscriptional Histone Methylation.},
  author={Gerald O. Hunter and Melanie J. Fox and Whitney R. Smith-Kinnaman and Madelaine M Gogol and Brian E Fleharty and Amber L Mosley},
  journal={Molecular and cellular biology},
  year={2016},
  volume={36 17},
  pages={2236-45}
}
In eukaryotes, the C-terminal domain (CTD) of Rpb1 contains a heptapeptide repeat sequence of (Y1S2P3T4S5P6S7)n that undergoes reversible phosphorylation through the opposing action of kinases and phosphatases. Rtr1 is a conserved protein that colocalizes with RNA polymerase II (RNAPII) and has been shown to be important for the transition from elongation to termination during transcription by removing RNAPII CTD serine 5 phosphorylation (Ser5-P) at a selection of target genes. In this study… CONTINUE READING

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