Phosphagen and intracellular pH changes during contraction of creatine-depleted rat muscle.

@article{Meyer1986PhosphagenAI,
  title={Phosphagen and intracellular pH changes during contraction of creatine-depleted rat muscle.},
  author={Ronald A. Meyer and Truman R. Brown and Beverly L Krilowicz and Martin J. Kushmerick},
  journal={The American journal of physiology},
  year={1986},
  volume={250 2 Pt 1},
  pages={C264-74}
}
To evaluate the functional role of phosphocreatine (PCr) and creatine in muscle metabolism, these compounds were depleted by feeding rats the creatine analogue, beta-guanidinopropionate (beta-GPA, 2% of diet). Changes in phosphate metabolites and intracellular pH were monitored in gastrocnemius muscle in situ by phosphorus nuclear magnetic resonance (31P-NMR) at 162 MHz using the surface coil technique. After 3 mo of feeding, 25 mumol/g of phosphorylated beta-GPA (beta-GPAP) had accumulated… CONTINUE READING

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